4-Piperidinol, 1-methyl- → HCID 23087228, 화합물

HRID 1950001노트

반응식

HRID 1950001 반응식
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

참가 물질

4

반응물 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

생성물 1

HCID 23087228HCID 23087228, 화합물

실험 절차

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

후처리

  1. customwas used according to an analogous synthetic method to Preparation Example 16

출처 및 근거

ORD 기록
ord-5180b8cb5d5d4ddfaf4ff088581d6be1
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399520B2

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