Water → 5-(Benzyloxy)pyridine-2-carboxylic acid

HRID 1950009노트

반응식

HRID 1950009 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.S(=O)(=O)([OH:20])N.Cl([O-])=O.[Na+]>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:20])=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 5987Sulfamic AcidHCID 123972545-(Benzyloxy)pyridine-2-carbaldehydeHCID 23668197Sodium Chlorite

생성물 1

HCID 183793525-(Benzyloxy)pyridine-2-carboxylic acid수율 73.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 5-benzyloxypyridine-2-carbaldehyde (3.8 g) in acetone (50 ml) was added water (50 ml), sulfamic acid (2.4 g) and sodium chlorite (2.2 g) were sequentially added thereto on an ice bath, and the solution was stirred for 6 hours at room temperature. The solid that was precipitated was filtered and rinsed with water to provide the title compound (3.0 g).

후처리

  1. additionwere sequentially added
  2. customThe solid that was precipitated
  3. filtrationwas filtered
  4. washrinsed with water

출처 및 근거

ORD 기록
ord-89d035fca62745bca76173e20e6a7228
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399520B2

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