6-(2-Amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ol → {2-[2-(tert-Butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine

HRID 1950082노트

반응식

HRID 1950082 반응식
[NH2:1][C:2]1C=C(OC)C=C[C:3]=1C1CCCC2C=C(O)C=CC=2C1.[Si:22]([O:29][C:30]1[CH:31]=[CH:32][C:33]2[CH2:39][CH:38]([C:40]3[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][C:41]=3N)[CH2:37][CH2:36][CH2:35][C:34]=2[CH:49]=1)([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23]>>[Si:22]([O:29][C:30]1[CH:31]=[CH:32][C:33]2[CH2:39][CH:38]([C:40]3[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[CH:42][C:41]=3[CH2:3][CH2:2][NH2:1])[CH2:37][CH2:36][CH2:35][C:34]=2[CH:49]=1)([C:25]([CH3:28])([CH3:26])[CH3:27])([CH3:23])[CH3:24]

참가 물질

3

반응물 2

HCID 579345186-(2-Amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-olHCID 66627107HCID 66627107, 화합물

생성물 1

HCID 66626847{2-[2-(tert-Butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine

실험 절차

Synthesized from 6-(2-amino-4-methoxyphenyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ol according to an analogous synthetic method to Example 201 described below, 2-[2-(tert-butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenylamine (1.3 g) was used according to an analogous synthetic method to Example 36 to provide the title compound (1.1 g).

출처 및 근거

ORD 기록
ord-e1712f772d8a4d86a91eb8109d88c27c
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399520B2

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