Thionyl Chloride → 5-(2-Azepan-1-ylethyl)pyridine-2-carbonyl chloride hydrochloride
반응식
BrC1N=CC(CCN2CCCCCC2)=CC=1.[N:17]1([CH2:24][CH2:25][C:26]2[CH:27]=[CH:28][C:29]([C:32]([O-:34])=O)=[N:30][CH:31]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.[Li+].S(Cl)([Cl:38])=O>>[ClH:38].[N:17]1([CH2:24][CH2:25][C:26]2[CH:27]=[CH:28][C:29]([C:32]([Cl:38])=[O:34])=[N:30][CH:31]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
Synthesized from 1-[2-(6-bromopyridin-3-yl)ethyl]azepane (400 mg) according to an analogous synthetic method to Preparation Example 51, to the total amount of lithium 5-(2-azepan-1-ylethyl)pyridine-2-carboxylate crude product was added thionyl chloride (8 ml), the solution was stirred for 30 minutes at 90° C., then the reaction solution was concentrated in vacuo to provide 5-(2-azepan-1-ylethyl)pyridine-2-carbonyl chloride hydrochloride (640 mg). Synthesized from this compound (320 mg) and pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (40 mg) according to an analogous synthetic method to Example 152, the title compound (7 mg) was obtained.