HCID 57933923, 화합물 → 6-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1950289노트

반응식

N1(CCOC2C=CC(CCNC3C=C(OC)C=CC=3C3CCC4C(=CC=C(OC)C=4)C3)=CC=2)CCCCCC1.[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56][CH2:57][N:58]([CH2:79][CH3:80])[C:59]3[CH:64]=[C:63]([O:65]C)[CH:62]=[CH:61][C:60]=3[CH:67]3[CH2:76][CH2:75][C:74]4[C:69](=[CH:70][CH:71]=[C:72]([O:77]C)[CH:73]=4)[CH2:68]3)=[CH:52][CH:51]=2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56][CH2:57][N:58]([CH2:79][CH3:80])[C:59]3[CH:64]=[C:63]([OH:65])[CH:62]=[CH:61][C:60]=3[CH:67]3[CH2:76][CH2:75][C:74]4[CH:73]=[C:72]([OH:77])[CH:71]=[CH:70][C:69]=4[CH2:68]3)=[CH:52][CH:51]=2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1

참가 물질

반응물 2

HCID 57933923HCID 57933923, 화합물

HCID 66625874{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine

생성물 1

HCID 579341276-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol수율 77%

실험 절차

Synthesized from {2-[4-(2-azepan-1-ylethoxy)phenyl]ethyl}[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine according to an analogous synthetic method to Example 36, {2-[4-(2-azepan-1-ylethoxy)phenyl]ethyl}ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (130 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (95 mg).

출처 및 근거

ORD 기록: ord-b83f5d8bdab34003ad98129a2da25333
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08399520B2

반응 노트

불러오는 중…