Cyclobutanone → cis-N-(2-Cyclobutylamino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 1950946

반응식

HRID 1950946 반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:24])[C:10]1[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:21])([F:20])[F:19])=[CH:12][C:11]=1[O:22][CH3:23].[C:25]1(=O)[CH2:28][CH2:27][CH2:26]1>>[CH:25]1([NH:1][C@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH:8][C:9](=[O:24])[C:10]2[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:20])([F:21])[F:19])=[CH:12][C:11]=2[O:22][CH3:23])[CH2:28][CH2:27][CH2:26]1

참가 물질

3

반응물 2

HCID 14496CyclobutanoneHCID 58062914cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2회

생성물 1

HCID 51000594cis-N-(2-Cyclobutylamino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

실험 절차

The title compound, colorless amorphous, MS: m/e=417.2 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate I) and cyclobutanone.

출처 및 근거

ORD 기록
ord-d4c0f8c390b943c4a2d6020a3e3fc633
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404673B2

연결된 노트

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