Sodium Methoxide → 5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine

HRID 1951187노트

반응식

HRID 1951187 반응식
Br.[CH3:2][C:3]1[CH:8]=[C:7]([C:9]2[S:13][C:12]([NH2:14])=[N:11][C:10]=2[CH3:15])[CH:6]=[C:5]([CH3:16])[N:4]=1.C[O-].[Na+]>CO>[CH3:2][C:3]1[CH:8]=[C:7]([C:9]2[S:13][C:12]([NH2:14])=[N:11][C:10]=2[CH3:15])[CH:6]=[C:5]([CH3:16])[N:4]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 866103325-(2,6-Dimethyl-pyridin-4-yl)4-methyl-thiazol-2-ylamine hydrobromide

생성물 1

HCID 450976375-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a stirred solution of 5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine hydrobromide (3.29 g, 11 mmol) in methanol (30 ml) is added sodium methoxide (2 ml of a 30% solution in methanol, 11 mmol). The resulting mixture is filtered through Celite™ filter material and concentrated in vacuo to yield the titled compound.

후처리

  1. filtrationThe resulting mixture is filtered through Celite™
  2. filtrationfilter material
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-53d76a972a314913863a7893bfa6fb95
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404684B2

반응 노트

불러오는 중…