Imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide → Imidazole-1-carboxylic acid [4-methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-amide
반응식
CC1N=C(N[C:14]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[O:15])SC=1C1C=CN=CC=1.[CH3:21][C:22]1[N:23]=[C:24]([NH2:39])[S:25][C:26]=1[C:27]1[CH:32]=[CH:31][N:30]=[C:29]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[N:28]=1>>[CH3:21][C:22]1[N:23]=[C:24]([NH:39][C:14]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[O:15])[S:25][C:26]=1[C:27]1[CH:32]=[CH:31][N:30]=[C:29]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[N:28]=1참가 물질
3
실험 절차
The titled compound is prepared by an analogous procedure to imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide (example 18a) by replacing 4-methyl-5-pyridin-4-yl-thiazol-2-ylamine (see example 16 for reference) with 4-methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-ylamine (25d).
출처 및 근거
- ORD 기록
- ord-1d8b8d12dc5d444fb3f3a8c21efd0184