Nicotinamidine hydrochloride → N-[4-Methyl-5-(2-pyridin-3-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

HRID 1951199

반응식

HRID 1951199 반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:19][C:20](=[O:22])[CH3:21])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9](N2CCOCC2)[N:8]=1.Cl.C(N)(=N)[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:19][C:20](=[O:22])[CH3:21])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[N:8]=1

참가 물질

3

반응물 2

HCID 202042Nicotinamidine hydrochlorideHCID 86610334N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

생성물 1

HCID 11415694N-[4-Methyl-5-(2-pyridin-3-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

실험 절차

The titled compound is prepared by an analogous procedure to N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide (25e) by replacing morpholinoformamidine hydrobromide (part 25c) with nicotinamidine hydrochloride.

출처 및 근거

ORD 기록
ord-82486817fdb842c9954f50ccb1a1b1a2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404684B2

연결된 노트

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