Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-4-methylbenzonitrile → 5-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-4-methylbenzonitrile | HCID 14004840 | — |
| 반응물 | 5-(5-(Cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acid | HCID 59761503 | — |
| 생성물 | 5-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide | HCID 67149011 | — |
반응 단계
The title compound was prepared by coupling 5-(5-(cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acid (Example 210, Step A) with commercially available 2-bromo-4-cyanotoluene using the method described in Step B of Example 136 to afford a white solid after purification by reverse phase preparative HPLC (Example 213). HPLC Ret time=3.36 min. LCMS [M+H]+ 416.29.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08404689B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-51e54881354c44a0be4c1890da46cc7d |
| 출처 메모 | uspto-grants-2013_03 |