1-Butanesulfonyl chloride → 3-Acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-1,6-naphthyridin-5-yl butane-sulfonate

HRID 1951410노트

반응식

HRID 1951410 반응식
[C:1]([C:4]1[CH:13]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[O:22][C:21]([CH3:24])=[CH:20][C:19]3=[O:25])[C:12]2[C:11](=[O:26])[NH:10][CH:9]=[CH:8][C:7]=2[NH:6][C:5]=1[CH3:27])(=[O:3])[CH3:2].[CH2:28]([S:32](Cl)(=[O:34])=[O:33])[CH2:29][CH2:30][CH3:31]>>[CH2:28]([S:32]([O:26][C:11]1[N:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]([C:14]1[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=1[O:22][C:21]([CH3:24])=[CH:20][C:19]3=[O:25])[C:4]([C:1](=[O:3])[CH3:2])=[C:5]([CH3:27])[NH:6]2)(=[O:34])=[O:33])[CH2:29][CH2:30][CH3:31]

참가 물질

3

반응물 2

HCID 754301-Butanesulfonyl chlorideHCID 596030093-Acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one

생성물 1

HCID 247984233-Acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-1,4-dihydro-1,6-naphthyridin-5-yl butane-sulfonate

실험 절차

The title compound is prepared in analogy to example 10 from 50 mg (0.13 mmol) of 3-acetyl-2-methyl-4-(2-methyl-4-oxo-4H-chromen-8-yl)-4,6-dihydro-1,6-naphthyridin-5(1H)-one and 24 mg (0.15 mmol) of butanesulfonyl chloride. 48 mg (72% of theory) of the product are obtained as a pale yellow solid.

후처리

  1. custom48 mg (72% of theory) of the product are obtained as a pale yellow solid

출처 및 근거

ORD 기록
ord-9f69315c4fe744a285d3c0930bc460b0
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404709B2

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