2-Azido-3-(4-bromo-5-methyl-thiophen-2-yl)-acrylic acid methyl ester → methyl 3-bromo-2-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]([N:13]=[N+]=[N-])=[CH:5][C:6]1[S:7][C:8]([CH3:12])=[C:9]([Br:11])[CH:10]=1>C1(C)C(C)=CC=CC=1>[CH3:1][O:2][C:3]([C:4]1[NH:13][C:10]2[C:9]([Br:11])=[C:8]([CH3:12])[S:7][C:6]=2[CH:5]=1)=[O:16]참가 물질
3
실험 절차
To a refluxing xylene (100 ml) was added the crude product of Step 2 (18 g) in 250 ml of xylene over a period of 20 min. After refluxing for 10 min, the reaction mixture was cooled and concentrated to volume of about 100 ml. The solid was collected by filtration to give 12.5 g of the title compound as a white solid.
후처리
- temperatureAfter refluxing for 10 min
- temperaturethe reaction mixture was cooled
- concentrationconcentrated to volume of about 100 ml
- filtrationThe solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-1920b700faca484098975edb2fd6cc41
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08404736B2
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