Tetrahydrofuran → 1-hydroxy-6-methoxy-1,3-diphenyl-1H-indene-2-carboxylic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:23])[CH:5]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17](OC)[CH:16]=1)[C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].[C:24]1([Mg]Cl)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C1C[O:35][CH2:34]C1>>[CH2:1]([O:3][C:4]([C:5]1[C:6]([OH:13])([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:24]2[C:29]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:28][CH:27]=[C:26]([O:35][CH3:34])[CH:25]=2)=[O:23])[CH3:2]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
The compound (300 mg, 0.97 mmol) obtained in Step 1 was dissolved in THF and 1.5 equivalents of phenylmagnesium chloride were added thereto, followed by stirring for 1 hr at 0° C. Then, the resulting mixture washed with saturated saline, and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 285 mg of the titled compound (yield: 76%).