Formic Acid → Methyl 5-formyl-3-methylthiophene-2-carboxylate

HRID 1952562노트

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HRID 1952562 반응식
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11](OCC)[O:12]CC)=[CH:8][C:9]=1[CH3:10])=[O:4].C(O)=O>O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11]=[O:12])=[CH:8][C:9]=1[CH3:10])=[O:4]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 682264465-Diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester

생성물 1

HCID 57618829Methyl 5-formyl-3-methylthiophene-2-carboxylate수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
0 °C

실험 절차

A solution of 5-diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester (4.41 g, 17.1 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (40 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 30 min. The mixture was concentrated under reduced pressure to afford the desired product which was not further purified (3.2 g, 100% yield).

후처리

  1. waitat rt for 30 min
  2. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-acb7632ba7dc4176b05e09c2efa6667f
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404859B2

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