Formic Acid → Methyl 5-formyl-3-(trifluoromethyl)-2-thiophenecarboxylate

HRID 1952575노트

반응식

HRID 1952575 반응식
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:14](OCC)[O:15]CC)=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])=[O:4].C(O)=O>O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:14]=[O:15])=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13])=[O:4]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 682265135-Diethoxymethyl-3-trifluoromethyl-thiophene-2-carboxylic acid methyl ester

생성물 1

HCID 71742491Methyl 5-formyl-3-(trifluoromethyl)-2-thiophenecarboxylate수율 99%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
0 °C

실험 절차

A solution of 5-Diethoxymethyl-3-trifluoromethyl-thiophene-2-carboxylic acid methyl ester (2.72 g, 8.71 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (25 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 60 min The reaction mixture was quenched by pouring into EtOAc. The organic layer was washed with water, dried over Na2SO4 and concentrated under reduced pressure to afford the desired product (2.05 g, 99% yield).

후처리

  1. customat rt for 60 min The reaction mixture was quenched
  2. additionby pouring into EtOAc
  3. washThe organic layer was washed with water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-779abd9d39f14d3d86c285b4561ec061
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404859B2

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