3-Cyanopyridine → 3-Pyridinecarboximidic acid, methyl ester

HRID 1952748노트

반응식

HRID 1952748 반응식
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C[O-].[Na+].[C:12](O)(=[O:14])C>CO>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:1](=[NH:8])[O:14][CH3:12])[CH:3]=1

참가 물질

5

반응물 3

HCID 793-CyanopyridineHCID 176Acetic AcidHCID 10942334Sodium Methoxide

생성물 1

HCID 103293433-Pyridinecarboximidic acid, methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of nicotinonitrile (11.35 g) and sodium methoxide (1.1 g) in methanol was allowed to stand at ambient temperature under nitrogen for 18 hours, then acetic acid (1.2 ml) was added, and the solvent was removed in vacuo. The residue was triturated with cyclohexane, undissolved solid was removed by filtration, and the solvent was removed in vacuo to leave methyl pyridine-3-carboximidate as an orange oil (10.6 g).

후처리

  1. customthe solvent was removed in vacuo
  2. customThe residue was triturated with cyclohexane, undissolved solid
  3. customwas removed by filtration
  4. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-4c206c5bd049428ca5840ce598c209d9
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114334

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