4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile → 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile
반응식
C(C1N(C)C=C(C=O)C=1)#N.NCC1N(C)C(C#N)=CC=1.[N:21]([CH2:24][C:25]1[CH:26]=[C:27]([C:31]#[N:32])[N:28]([CH3:30])[CH:29]=1)=[N+]=[N-]>>[NH2:21][CH2:24][C:25]1[CH:26]=[C:27]([C:31]#[N:32])[N:28]([CH3:30])[CH:29]=1참가 물질
4
실험 절차
4-Aminomethyl-1-methylpyrrole-2-carbonitrile was prepared starting from 5-cyano-1-methylpyrrole-3-carbaldehyde similar to the synthesis of 5-aminomethyl-1-methylpyrrole-2-carbonitrile. However, the 4-azidomethyl-1-methylpyrrole-2-carbonitrile was advantageously reduced by a Staudinger reaction (see, for example, S. Nagarajan et al., J. Org. Chem. 52 (1987) 5044-6).
출처 및 근거
- ORD 기록
- ord-0b7164282a294d7d8b8c4773345d21ac
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06114358
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