Formaldehyde → Hydroxyethyl methyltolylamine

HRID 1952981노트

반응식

HRID 1952981 반응식
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1.[H][H].[CH2:14]=O>[Pd].O>[CH3:14][N:4]([CH2:3][CH2:2][OH:1])[C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 2200082-p-Tolylamino-ethanolHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 76094Hydroxyethyl methyltolylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

N-(2-hydroxyethyl)-p-toluidine, 50 g, was combined with 1 g 5% palladium on carbon catalyst and charged to a pressure reactor. The pressure reactor was heated to 120° C. and fed hydrogen gas to maintain 120 psig pressure. Formaldehyde, 178 g 37% solution in water, was fed to the pressure reactor over 10 hours. After hydrogen uptake ceased, the reaction mass was filtered to remove catalyst and decanted to separate the aqueous phase.

후처리

  1. additioncharged to a pressure reactor
  2. temperatureto maintain 120 psig pressure
  3. filtrationthe reaction mass was filtered
  4. customto remove catalyst
  5. customdecanted
  6. customto separate the aqueous phase

출처 및 근거

ORD 기록
ord-b9134d0e4b9741c2b763722607ec956c
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114470

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