Chlorotrimethylsilane → 1-Bromo-4-((trimethylsilyl)oxy)benzene

HRID 1953370

반응식

HRID 1953370 반응식
[CH3:1][Si:2](Cl)([CH3:4])[CH3:3].[Br:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH3:1][Si:2]([O:13][C:10]1[CH:11]=[CH:12][C:7]([Br:6])=[CH:8][CH:9]=1)([CH3:4])[CH3:3]

참가 물질

5

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 78084-Bromophenol

생성물 1

HCID 873501-Bromo-4-((trimethylsilyl)oxy)benzene

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 1140Toluene용매

실험 절차

Trimethylsilyl chloride (11 ml, 87 mmol) was added dropwise to a stirred solution of 4-bromophenol (10.0 g, 58 mmol) in toluene (25 ml) and pyridine (20 ml) at 0° C. The stirred mixture was heated to ambient temperature during 3 hours. The reaction mixture was filtered and the organic solution evaporated to yield pure 4-bromophenyl trimethylsilyl ether. The silyl ether can be further purified by distillation (b.p. 122° C., 20 mmHg). Yield after distillation: 13.70 g (75%)

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe organic solution evaporated

출처 및 근거

ORD 기록
ord-d5dee2e9301447589d4d50ea9b256321
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117412

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