Ethanol → HCID 23298086, 화합물

HRID 1953413노트

반응식

HRID 1953413 반응식
C(N[C:5]1[C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=[CH:7][N:6]=1)(=O)C.[Cl-].[NH4+:28].[CH2:29]([OH:31])[CH3:30]>[Fe].O>[C:29]([NH:28][C:7]1[N:6]=[CH:5][C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=1)(=[O:31])[CH3:30]

참가 물질

6

반응물 3

HCID 702EthanolHCID 25517Ammonium ChlorideHCID 232980872-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine

생성물 1

HCID 23298086HCID 23298086, 화합물

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

실험 절차

A mixture of 2-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine (1.86 g), iron powder (1.39 g) and ammonium chloride (0.26 g), ethanol (20 ml) and water (6 ml) was stirred under reflux for an hour. The reaction was filtered, concentrated and extracted with chloroform. The extracts were washed with saturated sodium bicarbonate solution, dried and evaporated to afford 2-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine as dark purple crystals (1.59 g).

후처리

  1. temperatureunder reflux for an hour
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated
  4. extractionextracted with chloroform
  5. washThe extracts were washed with saturated sodium bicarbonate solution
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-72f7a37a2ca0483ba7f2a2b1bb9946e1
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117875

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