Acetic Acid → HCID 10527264, 화합물

HRID 1953666노트

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HRID 1953666 반응식
[CH3:1][N:2]1[C:6]2=[N:7][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:17][O:18][C:19]1[CH:51]=[CH:50][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[N:26](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:25]2=[O:49])=[CH:21][CH:20]=1.C(O)(=O)C>O>[CH3:1][N:2]1[C:6]2=[N:7][C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[CH2:17][O:18][C:19]1[CH:51]=[CH:50][C:22]([CH2:23][CH:24]2[S:28][C:27](=[O:29])[NH:26][C:25]2=[O:49])=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 107947135-{4-(3-Methyl-5-phenylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl}-3-triphenylmethylthiazolidine-2,4-dione

생성물 1

HCID 10527264HCID 10527264, 화합물수율 72.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A procedure similar to that described in Example 12 was repeated, except that 0.9 g of 5-{4-(3-methyl-5 -phenylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl}-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 111) was treated with 36 ml of a 3:1 by volume mixture of acetic acid and water. After working up the product as described in Example 12, the resulting crude product was crystallized by trituration with ethyl acetate, to give 420 mg of the title compound, melting at 211-213° C.

후처리

  1. customthe resulting crude product was crystallized by trituration with ethyl acetate

출처 및 근거

ORD 기록
ord-e61f64e5487943c9afc3e69df10c8f9f
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117893

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