반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16]C)[C:10]([O:14]C)=[N:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[CH:20]([P:22](=[O:27])([O:25]C)[O:23]C)[CH3:21])[CH:5]=1)([O-:3])=[O:2].C([Si](CC)(CC)[Br:33])C>ClCCl>[BrH:33].[O:14]=[C:10]1[C:9](=[O:16])[NH:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][C:6]=2[CH2:18][N:19]([CH2:28][CH3:29])[CH:20]([P:22](=[O:23])([OH:25])[OH:27])[CH3:21])[NH:11]1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
160 mg (0.37 mmol) of dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-α-(ethylamino)ethylphosphonate are dissolved in 8 ml of dichloromethane and stirred at room temperature for one hour with 0.19 ml (4 eq.) of triethylbromosilane. The solvent and excess reagent are evaporated and the residue is briefly dried in a high vacuum, dissolved in 5 ml of an about 33% hydrogen bromide solution in acetic acid, and stirred at room temperature for 18 hours. The reaction mixture is diluted with diethyl ether, and the solid is filtered off, washed with diethyl ether and dried. The title compound is obtained as a beige solid; m.p.=191° (dec.).
후처리
- customThe solvent and excess reagent are evaporated
- customthe residue is briefly dried in a high vacuum
- dissolutiondissolved in 5 ml of an about 33% hydrogen bromide solution in acetic acid
- additionThe reaction mixture is diluted with diethyl ether
- filtrationthe solid is filtered off
- washwashed with diethyl ether
- customdried
출처 및 근거
- ORD 기록
- ord-805450e2d57f40898fcf73124a490141
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06117873
연결된 노트
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