Potassium Carbonate → 2-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

HRID 1953841노트

반응식

HRID 1953841 반응식
[CH:1]1([C:4]2C(OC3C=CC(C4C=CC=CC=4C4N=NN(C(OC(=O)C(C)(C)C)C(C)C)N=4)=CC=3)=C(C(O)=O)C3C(=CC=CC=3)N=2)[CH2:3][CH2:2]1.[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:65]=[CH:64][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=5)([C:84]5[CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=5)[C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[N:76]=4)=[CH:62][CH:61]=3)=[C:57]([C:96]([OH:98])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:48][CH2:47]1.[C:99](=[O:102])([O-:101])[O-:100].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:61]=[CH:62][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=5)([C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[C:84]5[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=5)[N:76]=4)=[CH:64][CH:65]=3)=[C:57]([C:96]([O:98][CH2:4][C:1]3[O:102][C:99](=[O:101])[O:100][C:2]=3[CH3:3])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:47][CH2:48]1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 100774042-Cyclopropyl-3-[[2'-[2-[1-(2,2-dimethyl-1-oxopropoxy)-2-methylpropyl]-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acidHCID 23298234HCID 23298234, 화합물

생성물 1

HCID 571027302-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To the title A compound of Example 17, 2-cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid (1.32 g, 1.91 mmol, 1 eq.), and the title B compound (1.84 g, 9.54 mmol, 5 eq.) in dimethylformamide (3.8 mL, 0.5M), potassium carbonate (0.66 g, 4.77 mmol, 2.5 eq.) was added. The mixture was stirred at room temperature for 21 hours, diluted with ethyl acetate and filtered. The filtrate was washed with ammonium chloride/water and saturated sodium chloride, dried (magnesium sulfate), filtered and concentrated to afford the title compound.

후처리

  1. filtrationfiltered
  2. washThe filtrate was washed with ammonium chloride/water and saturated sodium chloride
  3. dry with materialdried (magnesium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8425e42db29e42a490c7e9a96d46d5bc
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117885

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