Pentadecanoic Acid → Pentadecanoyl chloride

HRID 1953925

반응식

HRID 1953925 반응식
S(Cl)([Cl:3])=O.[C:5]([OH:21])(=O)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>C1(C)C=CC=CC=1>[C:5]([Cl:3])(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

참가 물질

4

반응물 2

HCID 13849Pentadecanoic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 263097Pentadecanoyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

C 18 resin: Pentadecanoyl chloride was synthesized by reacting 10 ml of 2 M thionyl chloride in 10 ml of toluene with 1.5 gm pentadecanoic acid. After 40 minutes of refluxing, the remaining thionyl chloride and toluene were removed by distillation. 4 gm of the 3-amino-propyl resin was then incubated overnight with the freshly prepared pentadecanoyl chloride in pyridine. The next day, the resin was twice washed with methylene chloride and then three times more with methanol and dried.

후처리

  1. temperatureAfter 40 minutes of refluxing
  2. customthe remaining thionyl chloride and toluene were removed by distillation
  3. washThe next day, the resin was twice washed with methylene chloride
  4. dry with materialthree times more with methanol and dried

출처 및 근거

ORD 기록
ord-d0cfdd032eed4c3b97c2047641393aec
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06119699

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