p-Toluenesulfonic acid monohydrate → 2-Isopropyl-1H-indene
반응식
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]1O)([CH3:3])[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[CH:1]([C:4]1[CH2:12][C:11]2[C:6]([CH:5]=1)=[CH:7][CH:8]=[CH:9][CH:10]=2)([CH3:3])[CH3:2]참가 물질
4
실험 절차
2-i-Propyl-1-indanol, non-purified, was dissolved in 300 ml of benzene to which was added 5 g of p-toluenesulfonic acid monohydrate and the resulting mixture was refluxed to allow dehydration reaction to occur. After the reaction was over, the reaction mixture was washed with saline, dried over magnesium sulfate, and concentrated in an evaporator. The reaction mixture was purified by column chromatography (silica gel, development solvent: n-hexane) to fractionate the target compound.
후처리
- temperaturethe resulting mixture was refluxed
- customdehydration reaction
- washwas washed with saline
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in an evaporator
- customThe reaction mixture was purified by column chromatography (silica gel, development solvent: n-hexane)
출처 및 근거
- ORD 기록
- ord-fbc53dcc22d840bfbac39e4f6bc62e74
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06121182
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