Bromine → HCID 23296012, 화합물

반응식

[Cl:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:13][CH3:14])[CH:7]=1)=[O:5].[Br:19]Br>C(Cl)Cl.N1C=CC=CC=1>[Br:19][C:10]1[CH:11]=[C:6]([C:4](=[O:5])[C:3]2[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=2[Cl:1])[CH:7]=[C:8]([CH2:13][CH3:14])[C:9]=1[OH:12]

참가 물질

실험 절차

At ambient temperature, to a stirred solution containing 4-(2-chlorobenzoyl)-2-ethylphenol (13.62 g, 52.24 mmol) and pyridine (0.25 mL, 3.23 mmol) in CH2Cl2 (870 mL) was added dropwise bromine (3.3 mL, 62.29 mmol). After 48 h, the reaction was washed with 10% aq. Na2SO4 (1×180 mL), H2O (2×350 mL), brine (1×300 mL), dried (Na2SO4) and concentrated to give 16.50 g (93%) of the title compound. 1H NMR: consistent.

후처리

washthe reaction was washed with 10% aq. Na2SO4 (1×180 mL), H2O (2×350 mL), brine (1×300 mL)
dry with materialdried (Na2SO4)
concentrationconcentrated

출처 및 근거

ORD 기록: ord-5eb377e2fdef4efe8aa60259148da72f
출처 데이터셋: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06121271

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참가 물질

반응물 2

HCID 24408Bromine

HCID 23296008HCID 23296008, 화합물

생성물 1

HCID 23296012HCID 23296012, 화합물수율 93%

시약·촉매·용매 2

HCID 1049Pyridine촉매

HCID 6344Dichloromethane용매

실험 절차

후처리

washthe reaction was washed with 10% aq. Na2SO4 (1×180 mL), H2O (2×350 mL), brine (1×300 mL)
dry with materialdried (Na2SO4)
concentrationconcentrated

출처 및 근거

ORD 기록: ord-5eb377e2fdef4efe8aa60259148da72f
출처 데이터셋: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06121271

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