Methanol → 1,6-dimethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

HRID 19547

반응식

HRID 19547 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:7](Br)[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2].[CH3:24][OH:25]>[N+]([O-])([O-])=O.[Ag+]>[CH2:1]([O:3][C:4]([C:6]1[CH:7]([O:25][CH3:24])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 887MethanolHCID 686984701-bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

생성물 1

HCID 116884041,6-dimethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester수율 24%

시약·촉매·용매 1

HCID 24470Silver Nitrate촉매

실험 절차

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (60 mg, 0.18 mmol) obtained in Step 1 was dissolved in methanol (10 mL), silver nitrate (37.20 mg, 0.22 mmol) was added thereto, stirred for 3 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 14 mg of the titled compound (yield: 24%).

후처리

  1. filtrationfiltered
  2. customThe organic layer was separated
  3. concentrationconcentrated under a reduced pressure
  4. customThe resulting residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-1046f77f00fd4ad4b67f07f851c18159
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745439B2

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