Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1-bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester | HCID 68698470 | — |
| 촉매 | Silver Nitrate | HCID 24470 | — |
| 생성물 | 1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester | HCID 11660101 | 52% |
반응 단계
1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745439B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-87633b90324c42a59e3bb02d07e2d09b |
| 출처 메모 | uspto-grants-2010_06 |