Oxalyl chloride → (E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

HRID 1954868노트

반응식

HRID 1954868 반응식
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([OH:15])=O.C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C)C=O>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:19])=[O:15]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acid

생성물 1

HCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

A suspension of (E)-2-(4,6-difluoro-1-indanylidene)acetic Acid (5.49 g, 0.026 mol) in a mixture of dichloromethane: dimethylformamide (50 mL: 5 drops) was treated with oxalyl chloride (6.6 g 0.052 mol, Aldrich) and allowed to stir at ambient temperature for 18 h. The resulting solution was concentrated in vacuo and the residue used without further purification.

후처리

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue used without further purification

출처 및 근거

ORD 기록
ord-e3fdb48fe6554226bde281be60a6501c
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124284

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