Ethyl 3-(2-fluorophenyl)prop-2-enoate → Ethyl 3-(2-fluorophenyl)propanoate

HRID 1954873

반응식

HRID 1954873 반응식
[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

5

반응물 2

HCID 590919Ethyl 3-(2-fluorophenyl)prop-2-enoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 14879014Ethyl 3-(2-fluorophenyl)propanoate수율 99%

시약·촉매·용매 2

HCID 86587499Platinum oxide monohydrate촉매HCID 702Ethanol용매

실험 절차

A mixture of ethyl 2-fluorocinnamate (29.25 g, 0.176 mol) and platinum oxide hydrate (0.25, EM Scientific) in 95% ethanol (150 mL) was placed on a Parr hydrogenation apparatus and shaken under 2-4 atm at hydrogen pressure. After the appropriate amount of hydrogen was consumed, the catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give 29.39 g (99%) of crude ethyl 3-(2-fluorophenyl)propionate. This material was used without further purification.

후처리

  1. customAfter the appropriate amount of hydrogen was consumed
  2. customthe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-3f6994e5961c472785da87f605f3ac44
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124284

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