(E)-2-(4,6-difluoro-1-indanylidene)acetic acid → (E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

HRID 1954880노트

반응식

HRID 1954880 반응식
F[C:2]1[CH:10]=[C:9](F)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:15])=[O:14].[F:16]C1C=C(F)C=C2C=1CC/C/2=C\C(O)=O>>[F:16][C:10]1[CH:2]=[C:3]2[C:7](=[CH:8][CH:9]=1)/[C:6](=[CH:12]/[C:13]([Cl:15])=[O:14])/[CH2:5][CH2:4]2

참가 물질

3

반응물 2

HCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acidHCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

생성물 1

HCID 23293623(E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

실험 절차

This compound was prepared in a similar manner to (E)-2-(4,6-difluoro-1-indanylidene)acetyl chloride in Example 5f by substituting (E)-2-(5-fluoro-1-indanylidene)acetic acid (5.77 g, 0.03 mol) for (E)-2-(4,6-difluoro-1-indanylidene)acetic acid. The resulting solution was concentrated in vacuo, and the residue was used without further purification.

후처리

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue was used without further purification

출처 및 근거

ORD 기록
ord-8fcf4761d31f46b2b202001c3df4c7c2
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124284

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