Oxalyl chloride → HCID 23293589, 화합물

HRID 1954900노트

반응식

HRID 1954900 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7]/[C:8]/2=[CH:11]\[C:12](O)=[O:13])=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:20])=O>ClCCl>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7]/[C:8]/2=[CH:11]\[C:12]([Cl:20])=[O:13])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 23293609Acetic acid, (6-fluoro-2,3-dihydro-3,3-dimethyl-1H-inden-1-ylidene)-, (2E)-

생성물 1

HCID 23293589HCID 23293589, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To an ice cold, stirred suspension of (E)-2-(6-fluoro-3,3-dimethyl-1-indanylidene)acetic acid (9.0 g, 0.0409 mol) in dichloromethane (200 ml) was added oxalyl chloride (15.6 g, 0.123 mol, Aldrich). The stirring suspension was allowed to warm to 25° C. during 2 h. The resulting solution was concentrated by spin evaporation in vacuo with the addition of dichloromethane (4×75 ml) to give (E)-2-(6-fluoro-3,3-dimethyl-1-indanylidene)acetyl chloride as an uncharacterized oil. Dichloromethane (approximately 70 g) was added to dissolve this residual oil and the resulting solution was divided equally and used without other purification in Examples 15i, 16 and 17.

후처리

  1. concentrationThe resulting solution was concentrated by spin evaporation in vacuo with the addition of dichloromethane (4×75 ml)

출처 및 근거

ORD 기록
ord-ad57b52361464173af6b0ab894caef4a
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06124284

반응 노트

불러오는 중…