3-(4-Fluorophenyl)butyryl chloride → 6-Fluoro-3-propyl-1-indanone

반응식

FC1C=CC(C(C)CC(Cl)=O)=CC=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]([CH2:26][CH2:27][CH3:28])[CH2:22][C:23](Cl)=[O:24])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:20]=[C:19]2[C:18]([CH:21]([CH2:26][CH2:27][CH3:28])[CH2:22][C:23]2=[O:24])=[CH:17][CH:16]=1

참가 물질

반응물 2

HCID 232936303-(4-Fluorophenyl)butyryl chloride

HCID 232936703-(4-Fluorophenyl) hexanoyl chloride

생성물 1

HCID 232935706-Fluoro-3-propyl-1-indanone수율 98.5%

실험 절차

This compound was prepared in an analogous manner to Example 18e with the replace of 3-(4-fluorophenyl)butyryl chloride with 3-(4-fluorophenyl) hexanoyl chloride (49.95 g, 0.218 mol). The dichloromethane extractions were combined, washed with deionized water (250 ml) and concentrated by spin evaporation in vacuo. The residue was coevaporated with dichloromethane (100 ml) to give 41.26 g (98%) of 6-fluoro-3-propyl-1-indanone as a golden yellow syrup:

후처리

customThis compound was prepared in an analogous manner to Example 18e with the
extractionThe dichloromethane extractions
washwashed with deionized water (250 ml)
concentrationconcentrated by spin evaporation in vacuo

출처 및 근거

ORD 기록: ord-78969ab1e14b40d998975c53ab665e81
출처 데이터셋: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06124284

반응 노트

불러오는 중…