p-Toluenesulfonic acid → 6-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester

HRID 19553

반응식

HRID 19553 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([OH:21])[CH:9]=2)=[O:5])C.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:1][O:3][C:4]([C:6]1[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][CH:11]=[C:10]([OH:21])[CH:9]=2)=[O:5]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 118452796-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

생성물 1

HCID 687002636-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester수율 98.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (500 mg, 1.70 mmol) prepared in Preparation Example 2 was dissolved in methanol (30 mL), p-toluenesulfonic acid (65 mg, 0.34 mmol) was added thereto, refluxed for 24 hrs, and the solvent was removed therefrom by evaporation. The resulting residue was purified by flash chromatography to obtain 470 mg of the titled compound (yield: 98.6%) as a red solid.

후처리

  1. temperaturerefluxed for 24 hrs
  2. customthe solvent was removed
  3. customby evaporation
  4. customThe resulting residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-c58bfd6276374db59e66f17c0eef611d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745439B2

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