Bromine → N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamide

HRID 1955786노트

반응식

HRID 1955786 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[NH:11][S:12]([CH3:15])(=[O:14])=[O:13].[Br:16]Br>O1CCOCC1>[Br:16][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:4]=1)=[O:10]

참가 물질

4

반응물 2

HCID 24408BromineHCID 19073226N-(5-acetyl-2-hydroxyphenyl)methanesulfonamide

생성물 1

HCID 19073169N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamide수율 90.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a stirred 60° C. dioxane (35 mL) solution of 1-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethanone (2.06 g, 8.7 mmol) was rapidly added Br2 (1.48 g, 9.2 mmol). After one hour, the solution was cooled, concentrated and diluted with H2O. After filtration, the product was washed thoroughly with H2O, then with i-PrOH (9 mL), and air-dried to obtain the title compound (2.43 g, 84%).

후처리

  1. customTo a stirred 60° C.
  2. temperaturethe solution was cooled
  3. concentrationconcentrated
  4. additiondiluted with H2O
  5. filtrationAfter filtration
  6. washthe product was washed thoroughly with H2O
  7. dry with materialwith i-PrOH (9 mL), and air-dried

출처 및 근거

ORD 기록
ord-b3ea20147bd9433e8acbac29c47f0f5f
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05776983

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