4-tert-Butylphenol → 2-[4-(Tert-Butyl)Phenoxy]Benzenecarbaldehyde

반응식

F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[C:10]([C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)([CH3:13])([CH3:12])[CH3:11]>>[C:10]([C:14]1[CH:15]=[CH:16][C:17]([O:20][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=[O:5])=[CH:18][CH:19]=1)([CH3:13])([CH3:11])[CH3:12]

참가 물질

반응물 2

HCID 73934-tert-Butylphenol

HCID 67970o-Fluorobenzaldehyde

생성물 1

HCID 27634262-[4-(Tert-Butyl)Phenoxy]Benzenecarbaldehyde수율 77%

실험 절차

Preparation analogous to Example 12a) from 2-fluoro-benzaldehyde and 4-tert-butylphenol. Yield: 77%, yellow oil after high vacuum distillation (93°-100° C., 0.9 mbar); TLC (silica gel; hexane/ethyl acetate=1:1; UV): Rf =0.65; 1H-NMR (CDCl3, 200 MHz): 1.35 (s, 9H); 6.75-7.55 (m, 7H); 7.92 (dd, 1H) MS: 254 (M+), 239.

후처리

distillationYield: 77%, yellow oil after high vacuum distillation (93°-100° C., 0.9 mbar)

출처 및 근거

ORD 기록: ord-af48c71dcdae43d4a692693e6b0e4068
출처 데이터셋: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05780501

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