Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-4-fluorobenzylamine → 3-(2-Chloro-4-fluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-4-fluorobenzylamine | HCID 139909 | — |
| 반응물 | 3-Ethoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione | HCID 17819403 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-(2-Chloro-4-fluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione | HCID 10805943 | — |
반응 단계
This compound was prepared according to the procedure for Example 59. From 2-chloro-4-fluorobenzylamine and 3-ethoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione in acetonitrile. The title compound was obtained, after recrystallization from petroleum ether, as a white solid (60%); mp 201°-203° C.; 1H NMR (DMSO-d6) δ0.81 (t, 3H), 1.30 (s, 6H), 1.68 (q, 2H), 4.76 (d, 2H), 7.25 (m, 1H), 7.50 (m, 3H), 7.78 (m, 1H) ppm; IR (KBr) 3250, 3040, 1790, 1660, 1580, 1530, 1490 cm-1 ; MS (m/z) 325 ([M+H]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05780505 |
| 출처 데이터셋 | uspto-grants-1998_07 |
| ORD ID | ord-c04173aff885422cbedb73b732e95d10 |
| 출처 메모 | uspto-grants-1998_07 |