4-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(Methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 19570

반응식

HRID 19570 반응식
Cl[C:2]1[C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[N:7]=1>C(O)C>[CH3:11][S:8]([C:6]1[N:7]=[CH:2][C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=1)(=[O:9])=[O:10]

참가 물질

3

반응물 1

HCID 219883544-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

생성물 1

HCID 219883562-(Methylsulfonyl)thieno[2,3-d]pyrimidine수율 85.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

후처리

  1. customwas bubbled for 5 minutes
  2. additionTo this solution was added 10% palladium on activated charcoal (15 g)
  3. customTo the resulting mixture was bubbled hydrogen gas over night
  4. filtrationThe reaction mixture was filtered through Celite
  5. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-398d0eeeef004e768af1392b96843f9b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745449B2

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