Methyl tryptophanate hydrochloride → N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan

HRID 1957006

반응식

HRID 1957006 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:35]=[C:36]([CH3:38])[CH:37]=1)[C:5]([N:7]([CH3:34])[C@@H:8]([C:17]([NH:19][C@H:20]([C:31]([OH:33])=[O:32])[CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)=[O:6].Cl.COC(=O)[C@H](C[C:46]1[C:54]2[C:49](=[CH:50][CH:51]=[CH:52][CH:53]=2)NC=1)N>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:35]=[C:36]([CH3:38])[CH:37]=1)[C:5]([N:7]([CH3:34])[C@@H:8]([C:17]([NH:19][C@H:20]([C:31]([OH:33])=[O:32])[CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:46][C:54]2[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=2)=[CH:12][CH:11]=1)=[O:6]

참가 물질

3

반응물 2

HCID 2734891Methyl tryptophanate hydrochlorideHCID 67675232N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosyl-(L)-tryptophan

생성물 1

HCID 67674609N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan

실험 절차

Coupling of N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosine (prepared by O-benzylation of N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosine (example 64)) with (L)-tryptophan methyl ester hydrochloride according to example 1 followed by hydrolysis of the methyl ester moiety according to example 12 gives N-(3,5-dimethylbenzoyl)-N-methyl-O-benzyl-(D)-tyrosyl-(L)-tryptophan; FAB-MS m/e 602 (M-H)-.

출처 및 근거

ORD 기록
ord-d5c8e86e343a4f9e9a86ba8ac1dd295f
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780498

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