Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydride → 2-(1-Benzhydrylazetidin-3-YL)ethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydride | HCID 166653 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 3-Cyanomethyl-1-benzhydryl azetidine | HCID 22257633 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(1-Benzhydrylazetidin-3-YL)ethanamine | HCID 22257634 | 87% |
반응 단계
5.7 g (21.7 mmol) of 3-cyanomethyl-l-benzhydryl azetidine was added slowly to a suspention of 2.9 g (76.0 mmol) of LiAlH4 in 80 mL of dry THF at roomtemperature. The reaction mixture was refluxed for 4 h. Excess hydride reagent was hydrolyzed by careful addition, with cooling, of NH4 Cl(aq), the gelatinous mixture was filtered and the filter cake was washed repeatedly with THF. The solvent was evaporated, the residue was dissolved in diethyl ether, washed with brine and dried with Na2SO4. Evaporation of the solvent gave 5.0 g (87%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05783563 |
| 출처 데이터셋 | uspto-grants-1998_07 |
| ORD ID | ord-aa7105c9403940bc892562f70c7c4301 |
| 출처 메모 | uspto-grants-1998_07 |