Acetamidine monohydrochloride → HCID 178499609, 화합물

HRID 1957172노트

반응식

HRID 1957172 반응식
[CH:1]([C:11]([O:13]C)=O)([C:7](OC)=[O:8])[CH2:2][C:3]([O:5][CH3:6])=[O:4].Cl.[C:16]([NH2:19])(=[NH:18])[CH3:17].C[O-].[Na+]>CO>[OH:13][C:11]1[C:1]([CH2:2][C:3]([O:5][CH3:6])=[O:4])=[C:7]([OH:8])[N:19]=[C:16]([CH3:17])[N:18]=1

참가 물질

5

반응물 3

HCID 67170Acetamidine monohydrochlorideHCID 2911921,1,2-Trimethyl ethane-1,1,2-tricarboxylateHCID 10942334Sodium Methoxide

생성물 1

HCID 178499609HCID 178499609, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Trimethyl ethane-1,1,2-tricarboxylate (204 g, 1 mol) and acetamidine hydrochloride (95 g, 1 mol) are added to a solution of sodium methylate (108 g, 2 mol) in methanol (600 ml) with stirring. The mixture is stirred for 16 hours at room temperature. Acidification with concentrated hydrochloric acid, filtration, washing with cold water and drying gives the methyl 4,6-dihydroxy-2-methyl-pyrimidin-5-yl-acetate (or tautomeric forms thereof) as a colorless solid (210 g), m.p.>200° C.

후처리

  1. stirringThe mixture is stirred for 16 hours at room temperature
  2. filtrationAcidification with concentrated hydrochloric acid, filtration
  3. washwashing with cold water
  4. customdrying

출처 및 근거

ORD 기록
ord-c566cc7fc5204cd3ab2a6b8bc5de8414
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783580

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