Sodium Methoxide → HCID 53913984, 화합물

HRID 1957173노트

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HRID 1957173 반응식
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[C:10]([CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:9](Cl)[N:8]=[C:7]([CH3:17])[N:6]=1>CO.COCCOC.C(OCC)C>[Cl:4][C:5]1[C:10]([CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:9]([O:2][CH3:1])[N:8]=[C:7]([CH3:17])[N:6]=1

참가 물질

6

반응물 2

HCID 10942334Sodium MethoxideHCID 19071353HCID 19071353, 화합물

생성물 1

HCID 53913984HCID 53913984, 화합물

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 80711,2-Dimethoxyethane용매

실험 절차

Sodium methylate in methanol (33 ml of a 5.4 molar solution) is added at room temperature to a solution of methyl 4,6-dichloro-2-methyl-pyrimidin-5-yl-acetate (35.5 g, 0.15 mol) in 1,2-dimethoxyethane (60 ml). After stirring for 30 minutes the mixture is diluted with diethyl ether and washed with water. Drying and distillation gives the methyl 4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl-acetate as a colorless oil (30 g), b.p. 108°-110° C./0.5 torr.

후처리

  1. washwashed with water
  2. customDrying
  3. distillationdistillation

출처 및 근거

ORD 기록
ord-a4ade4981adf4c1faeedbe9a830a971d
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783580

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