Dimethylamine → HCID 67667357, 화합물

HRID 1957177노트

반응식

HRID 1957177 반응식
Cl[C:2]1[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[C:6](Cl)[N:5]=[C:4]([CH3:14])[N:3]=1.C(C1C=C(O)C=CC=1)(C)C.C(=O)([O-])[O-].[K+].[K+].[CH3:31][NH:32][CH3:33]>CN(C)C=O.O>[CH3:31][N:32]([CH3:33])[N:5]1[CH:6]=[C:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:2]=[N:3][CH:4]1[CH3:14]

참가 물질

7

반응물 4

HCID 674DimethylamineHCID 11430Potassium CarbonateHCID 120593-IsopropylphenolHCID 19071353HCID 19071353, 화합물

생성물 1

HCID 67667357HCID 67667357, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Methyl 4,6-dichloro-2-methyl-pyrimidin-5-yl-acetate (23.5 g, 0.1 mol), 3-isopropylphenol (13.6 g, 0.1 mol) and potassium carbonate (20.7 g, 0.15 mol) are heated in dimethylformamide (30 ml) at 100° C. for 45 minutes. The mixture is cooled and an aqueous solution of dimethylamine (50 ml of a 40% solution) is added. Stirring is continued for 16 hours at room temperature. Addition of water, filtering and drying gives the methyl 1-dimethylamino-2-methyl-pyrimidin-5-yl-acetate as a brownish solid (28 g).

후처리

  1. temperatureThe mixture is cooled
  2. filtrationfiltering
  3. customdrying

출처 및 근거

ORD 기록
ord-a670d7abaf4c445c8307aea3b7a4ee8b
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783580

반응 노트

불러오는 중…