Water → Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

HRID 1957215노트

반응식

HRID 1957215 반응식
Cl[C:2]1[N:3]([CH3:16])[C:4]2[C:9]([C:10]=1[CH:11]=O)=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2.C([O-])([O-])=O.[K+].[K+].[SH:23][CH2:24][C:25]([O:27][CH3:28])=[O:26].O>CO>[CH3:16][N:3]1[C:4]2[C:9](=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2)[C:10]2[CH:11]=[C:24]([C:25]([O:27][CH3:28])=[O:26])[S:23][C:2]1=2

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 108238742-Chloro-1-methyl-5-nitroindole-3-carbaldehyde

생성물 1

HCID 19068989Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.4 g of (66) was added to a slurry of excess K2CO3 in 100 ml of MeOH. 2 ml of methyl 2-mercaptoacetate was added and the mixture left with stirring overnight. Addition of water precipitated the product, which was washed with MeOH and water to give 640 mg of (67). M. p. 269°-71° C.

후처리

  1. waitthe mixture left
  2. customprecipitated the product, which
  3. washwas washed with MeOH and water

출처 및 근거

ORD 기록
ord-777f1d48539046ee8810b748702d8889
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783575

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