4-Chlorobenzenesulfonyl chloride → HCID 19068768, 화합물
반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[Cl:15][C:14]1[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([NH:1][S:27]([C:24]3[CH:25]=[CH:26][C:21]([Cl:20])=[CH:22][CH:23]=3)(=[O:29])=[O:28])[CH:3]=2)=[N:10][CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:13]=1참가 물질
3
실험 절차
In a similar way to Example 37, reaction of 2.5 g of 2-(3-amino-4-chlorophenyl)-3-chloro-5-trifluoromethylpyridine and 1.9 g of 4-chlorobenzenesulfonyl chloride, and purification of the crude product by recrystallization from ether, resulted in 1.2 g of colorless crystals. Yield: 31%; melting point: 156°-157° C.
후처리
- customby recrystallization from ether
출처 및 근거
- ORD 기록
- ord-dd360e88ddc0488e9526175be959ba73
- 출처 데이터셋
- uspto-grants-1998_07