Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl L-tartrate → HCID 19068731, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl L-tartrate | HCID 11851 | — |
| 반응물 | 3-Chloro-2-(4-chloro-3-dimethoxymethylphenyl)-5-trifluoromethylpyridine | HCID 19068745 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 19068731 | HCID 19068731 | 77% |
반응 단계
3.0 g of 3-chloro-2-(4-chloro-3-dimethoxymethylphenyl)-5-trifluoromethyl-pyridine, 5.4 g of dimethyl L(+)-tartrate and 100 mg of p-toluenesulfonic acid in 180 ml of anhydrous toluene were refluxed for 10 hours. The solution was cooled and then washed with 50 ml of 10% by weight sodium bicarbonate solution and three times with 50 ml of water each time, dried over sodium sulfate and concentrated. Chromatography on silica gel resulted in 3.0 g (77%) of colorless crystals; melting point: 48°-53° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05783522 |
| 출처 데이터셋 | uspto-grants-1998_07 |
| ORD ID | ord-bb05fe3833aa4722814b4a3f39fe5804 |
| 출처 메모 | uspto-grants-1998_07 |