참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Fluorouridine | HCID 9427 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | N-Carbobenzoxy-L-valine | HCID 726987 | — |
| 용매 | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| 생성물 | HCID 13134890 | HCID 13134890 | 42.1% |
반응 단계
To a solution of 5-fluorouridine (5-FU, 521 mg, 1.98 mmol) in 6 mL of anhydrous THF-DMF (1:1 under nitrogen was added N-(benzyioxycarbonyl)-L-valine (500 mg, 1.99 mmol), triphenylphosphine (521 mg, 1.98 mmol), and diisopropyl azodicarboxylate (402 mg, 1.98 mmol). The mixture was stirred overnight at 25 °C. The volatile components were removed under reduced pressure and the residue chromatographed over silica gel eluting with methyl alcohol:chloroform (1:5 ) to provide 5'-O-[N-(benzyloxycarbonyl)-L-valinyl]-5-fluorouridine (413 mg., 40% yield) as a white solid melting at about 64° C.-67° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05783689 |
|---|
| 출처 데이터셋 | uspto-grants-1998_07 |
|---|
| ORD ID | ord-85f5bf33f64543889c528f1d383e83ac |
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| 출처 메모 | uspto-grants-1998_07 |
|---|
