Acetyl chloride → HCID 54052838, 화합물

HRID 1957357노트

반응식

HRID 1957357 반응식
[C:1](Cl)(=[O:3])[CH3:2].[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[N:12][N:13]2[CH:17]=[N:16][NH:15][C:14]2=[O:18])[CH:6]=1>N1C=CC=CC=1>[C:1]([N:15]1[C:14](=[O:18])[N:13]([N:12]=[CH:11][C:7]2[CH:6]=[N:5][CH:10]=[CH:9][CH:8]=2)[CH:17]=[N:16]1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 54560653HCID 54560653, 화합물

생성물 1

HCID 54052838HCID 54052838, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2.4 g of acetyl chloride are added to a suspension of 3.8 g of 4-(pyridin-3-ylmethyleneamino)-1,2,4-triazol-3-one in 50 ml of pyridine. The resulting solution is stirred for 14 hours at 20° and then concentrated by evaporation. Water is added to the residue and extraction is carried out with chloroform. The organic phase is concentrated by evaporation and the residue is stirred with ether. The crystals are filtered off with suction and then dried under a high vacuum. 4 g of the title compound having a melting point of 164°-166° are thus obtained.

후처리

  1. concentrationconcentrated by evaporation
  2. additionWater is added to the residue and extraction
  3. concentrationThe organic phase is concentrated by evaporation
  4. stirringthe residue is stirred with ether
  5. filtrationThe crystals are filtered off with suction
  6. customdried under a high vacuum
  7. customare thus obtained

출처 및 근거

ORD 기록
ord-db68af07607d440ca2577aecf2344f77
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783704

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