Methyl carbazate → N'-[2-(5-Methoxy-2-oxo-[1,3,4]thiadiazol-3-yl)-1-methyl-ethylidene]-hydrazinecarboxylic acid methyl ester

HRID 1957370노트

반응식

HRID 1957370 반응식
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[CH3:7][O:8][C:9]1[S:13][C:12](=[O:14])[N:11]([CH2:15][C:16](=O)[CH3:17])[N:10]=1>CO>[CH3:6][O:5][C:1]([NH:2][N:3]=[C:16]([CH3:17])[CH2:15][N:11]1[N:10]=[C:9]([O:8][CH3:7])[S:13][C:12]1=[O:14])=[O:4]

참가 물질

4

반응물 2

HCID 80519Methyl carbazateHCID 193507245-Methoxy-3-(2-oxopropyl)-3H-[1,3,4]thiadiazol-2-one

생성물 1

HCID 53777430N'-[2-(5-Methoxy-2-oxo-[1,3,4]thiadiazol-3-yl)-1-methyl-ethylidene]-hydrazinecarboxylic acid methyl ester수율 78.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

9.1 g of methyl carbazate are added to a solution of 18.8 g of 5-methoxy-3-(2-oxo-propyl)-3H-[1,3,4]thiadiazol-2-one (Comp. 7.001) in 150 ml of methanol and the mixture is then stirred at room temperature for 36 hours. The reaction mixture is concentrated by evaporation and the residue is stirred with isopropanol and filtered with suction to yield 20.5 g of crystals of the title compound having a melting point of 142°-143°.

후처리

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. stirringthe residue is stirred with isopropanol
  3. filtrationfiltered with suction

출처 및 근거

ORD 기록
ord-b0fc1af8f4fb4187a044008c4a1a69e0
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05783704

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