Allyl bromide → 4-Allyloxy-2,5-dichloronitrobenzene

HRID 1957471

반응식

HRID 1957471 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([Cl:11])=[CH:4][C:3]=1[OH:12].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[CH:20]=[CH2:21]>C(#N)C>[CH2:21]([O:12][C:3]1[C:2]([Cl:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[C:5]([Cl:11])[CH:4]=1)[CH:20]=[CH2:19]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 221082,5-Dichloro-4-nitrophenol

생성물 1

HCID 190676764-Allyloxy-2,5-dichloronitrobenzene수율 93.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The product of step (a) (59.3 g, 285 mmol), 550 ml acetonitrile, 43 g (314 mmol) of potassium carbonate and 27.2 ml (314 mmol) of allyl bromide were combined and heated to reflux, and then the reaction was evaporated under reduced pressure. The mixture was extracted with diethyl ether, washed with water, and separated. The organics were dried over magnesium sulfate and stripped to yield 66.1 g of 4-allyloxy-2,5-dichloronitrobenzene product.

후처리

  1. temperatureheated
  2. temperatureto reflux
  3. customthe reaction was evaporated under reduced pressure
  4. extractionThe mixture was extracted with diethyl ether
  5. washwashed with water
  6. customseparated
  7. dry with materialThe organics were dried over magnesium sulfate

출처 및 근거

ORD 기록
ord-b1d3a2b801a248e68ada93e3f0958bd5
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05786301

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